C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/102, 260/104
C07D 501/20 (2006.01) C07D 209/48 (2006.01) C07D 277/20 (2006.01)
Patent
CA 1147323
Abstract 7-[2-(2-Amino-4-Thiazolyl)-2-[(1-Carboxy-1,1- Dialkyl)Alkoxyimino]Acetamido]Cephem Sulfoxides Compounds of the formula Image wherein R is hydrogen, sodium, potassium, or certain ester groups; R1 is in the -configuration and is hydrogen or methoxy; R2 and R3 are independently selected from methyl, ethyl, i-propyl, and n-propyl; R4 is hydrogen, sodium, potassium or certain ester groups, and X is hydrogen, -O-?-lower alkyl, -O-?NH2, Image , Image , Image Image ; R6 is hydrogen or lower alkyl; R7 is hydrogen, lower alkyl, -(CH2)n-?-OR8, -(CH2)n-?-OR8, or -(CH2)n-N-(lower alkyl)2; R8 is hydrogen, sodium or potassium, n is an integer from 1 to 4; are disclosed. These compounds are useful as antibacterial agents.
348408
Cimarusti Christopher M.
Koster William H.
Sykes Richard B.
Osler Hoskin & Harcourt Llp
Squibb (e.r.) & Sons Inc.
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