7-(2-methyl-4-aminopyrrolidinyl)naphthyridine and quinoline...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61K 31/435 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1340784

Naphthyridine and quinoline compounds having the formula: (see formula I) wherein A is CH or N; Z is an amine having the formula: (see formula II) R is o, p-difluorophenyl or p-fluorophenyl; and R1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.

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