7-¬(4'-trifluoromethyl-biphenyl-2-carbonyl)amino|-quinoline-...

Details 7-¬(4'-trifluoromethyl-biphenyl-2-carbonyl)amino|-quinoline-... 7-¬(4'-trifluoromethyl-biphenyl-2-carbonyl)amino|-quinoline-...

C - Chemistry, Metallurgy

07

D

C07D 215/54 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61K 31/54 (2006.01) A61P 1/18 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 411/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 455/02 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (20

Patent

CA 2325358

This invention relates to compounds of Formula I (see formula I) that inhibit the secretion of apolipoprotein B, to pharmaceutical compositions comprising the compounds, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperliproproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia, pancreatitis, myocardial infarction, stroke, restenosis, or Syndrome X. This invention also relates to methods of reducing the secretion of apolipoprotein B and/or inhibiting microsomal triglyceride transfer protein.

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