C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4745 (2006.01)
Patent
CA 2560206
The invention provides compounds of the formula (1) in which R1 is hydrogen, 1- 4C-alkyl, 3-7C-cycloalkyl, 1-4C-alkoxy-1-4C-alkyl or 1-4C-alkoxycarbonyl, 2-4C- ~alkenyl, 2-4C-alkinyl, fluoro-1-4C-alkyl or hydroxy-1-4C-alkyl R2 is hydrogen, 1-4C-alkyl, 3-7C-cydoalkyl, 3-7C-cycloalkyl-1-4C-alkyl, halogen, 2- 4C-alkenyl, 2-~4C-alkynyl, hydroxy-1-4C-alkyl, hydroxy-3-4-C-alkenyl, hydroxy- 3-4C-alkinyl, 1-4-C~alkoxycarbonyl, fluoro-1-4C-alkyl, cyanomethyl, hydroxy, 1- 4C-alkoxy, amino, mono- or di-1-4C-~alkylamino, 1-4C-alkylcarbonylamino, 1-4C- alkoxycarbonylamino, carboxyl, mono- or di-1-4C~alkylamino-1-4C-alkyl, 1-4C- alkylcarbonyl, 2-4C-alkenylcarbonyl, 2-4C-alkinylcarbonyl. or the radical -CO- NR21 R22, R3 is hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxy-1-4C- alkoxy-1-4C-alkyl, carboxyl, 1-~4C-alkoxycarbonyl or the radical -CO-NR31 R32, Arom is a R4-, R5-, R6- and R7- substituted mono- or bicyclic aromatic radical selected from the group consisting of phenyl, naphthyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, indolyl, benzimidazolyl, furanyl (furyl), benzofuranyl.(benzofuryl), thiophenyl (thienyl), benzothiophenyl (benzothienyl), thiazolyl, isoxazolyl, pytidinyl, pyrimidinyl, quinolinyl and isoquinolinyl. The compounds inhibit the secretion of gastric acid.
L'invention a trait à des composés représentés par la formule (I), dans laquelle les substituants et les symboles sont tels que définis dans le descriptif de l'invention. Lesdits composés inhibent la sécrétion d'acide gastrique.
Altana Pharma Ag
Gowling Lafleur Henderson Llp
Nycomed Gmbh
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