7,8 and 9-substituted tetracycline compounds

Details 7,8 and 9-substituted tetracycline compounds 7,8 and 9-substituted tetracycline compounds

C - Chemistry, Metallurgy

07

C

C07C 237/26 (2006.01) A61K 31/65 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2415086

7,8 and 9-substituted tetracyline compounds of the formula (I) wherein: R?4¿ and R?4'¿ are each methyl; R?5¿ is hydrogen or hydroxyl; R?6¿ and R?6'¿ are each independently hydrogen, methyl, or hydroxyl; R?7¿ is hydrogen, lower alkenyl, lower alkynyl, phenyl, halophenyl, acyl, phenylalkynyl, heteroaryl, or dimethylamino; and R?8¿ is hydrogen, phenyl, nitrophenyl, halo, or lower alkynyl; and R?9¿ is hydrogen, amino, acetamide, or lower alkynyl; and provided that at least one of R?7¿, R?8¿, or R?9¿ is not hydrogen, methods of treating tretracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.

L'invention concerne des composés de tétracycline substitués en 7, 8 et 9, des méthodes de traitement de troubles sensibles à la tétracycline, et des compositions pharmaceutiques contenant lesdits composés de tétracycline substitués en 7,8 et 9.

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