7,8-dihydro-2,5,8-trisubstituted-7-oxo-pyrido...

Details 7,8-dihydro-2,5,8-trisubstituted-7-oxo-pyrido... 7,8-dihydro-2,5,8-trisubstituted-7-oxo-pyrido...

C - Chemistry, Metallurgy

07

D

260/242.5

C07D 471/04 (2006.01)

Patent

CA 1120475

Abstract The pyrido[2,3-d]pyrimidines are of the formula: Image wherein R2 is hydrogen, hydroxy, alkyl, alkylthlo, phenyl, 4-me- thoxyphenyl, 4-chlorophenyl, 1-pyrrolidinyl or methylphenylarnino; R5 is hydroxy, alkylamino, 2-hydroxyethylamino, 2-alkoxyethyl- amino, dialkylamino, 4-methyl-1-piperazinyl, 4-morpholinyl or 1- pyrrolidinyl or amino with the provisos that if R8 is alkyl and R2 is phenyl then R5 is other than amino and if R8 is alkyl and R2 is alkylthio then R5is other than 1-pyrrolidinyl; R6 is al- koxy, amino, mono- or dialkylamino, 2-hydroxyethylamino, 2-al- koxyethylamino or 2 (dialkylamino)-ethylamino; and R8 is hydro- gen, alkyl, 2 alkoxyethyl, allyl, propargyl, phenyl, 4-methoxy- phenyl, 4-chlorophenyl, benzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-(4-morpholinyl)-phenyl or piperonyl. The compounds are useful as anti-secretory agents. Some also exhibit anti-allergy acti- vity. Processes for preparing the compounds are described and also novel intermediates useful in the processes.

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