C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 501/16 (2006.01) A61K 31/545 (2006.01) A61K 31/695 (2006.01) C07D 501/00 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2054895
A 7-acyl-3-substituted carbamoyloxy cephem compound represented by the following formula (1): Image wherein: A means a -CH= or -N= group: R1 denotes a hydroxyl, lower alkoxyl, or protected hydroxyl group: R2 and R3 are the same or different and individually represent a lower alkyl, hydroxyl-substituted lower alkyl, a carbamoyl-substituted lower alkyl group or cyano-substituted lower alkyl group, R2 is a hydrogen atom and R3 is a lower alkoxyl or alkyl group optionally substituted by ~ one or more halogen atoms, or the group Image means a 4-6 membered heterocyclic group, which contains one nitrogen atom, or a morpholino group, said hetero-cyclic group or morpholino group being optionally substituted by one or more lower alkyl, hydroxyl and/or hydroxyl-substituted lower alkyl groups; and R4 denotes a carboxyl or protected carboxyl group: or a pharmaceutically acceptable salt thereof: and a process for the preparation thereof: as well as an antibacterial composition containing the above cephem compound.
Kamata Atsushi
Katsu Kanemasa
Komatu Yuuki
Machida Yoshimasa
Negi Shigeto
Eisai Co. Ltd.
Marks & Clerk
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