7-acylamine substituted cephalosporin compounds and their...

C - Chemistry – Metallurgy – 07 – D

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260/104.5

C07D 501/06 (2006.01) C07D 501/44 (2006.01)

Patent

CA 1049503

Abstract of the Disclosure Cephalosporin derivatives are provided of the formula: Image (IXb) wherein R2 is lower alkyl and R4 is hydrogen, lower alkanoyl- oxy, triazolyl or thiadiazolylthio which is unsubstituted or substituted with lower alkyl, a halo(lower)alkyl ester thereof or non-toxic, pharmaceutically acceptable salts thereof: processes for preparing the novel derivatives are similarly provided. The novel derivatives exhibit a strong antimicrobial activity against a wide variety of microorganisms including gram-negative and gram-positive bacteria; in particular their antibiotic potency is maintained at a high level for a long period of time on oral administration.

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