C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/101, 167/187
C07D 501/22 (2006.01) C07D 209/48 (2006.01) C07D 213/75 (2006.01) C07D 239/42 (2006.01) C07D 257/06 (2006.01) C07D 271/06 (2006.01) C07D 271/07 (2006.01) C07D 277/20 (2006.01) C07D 277/46 (2006.01) C07D 277/48 (2006.01) C07D 277/56 (2006.01) C07D 285/08 (2006.01) C07D 417/12 (2006.01)
Patent
CA 1235414
ABSTRACT OF THE DISCLOSURE 7-Acylamino-3-vinylcephalosporanic acid derivatives and their process of preparation are provided of formula: Image in which R1 is amino-substituted-heterocyclic group which may have halogen protected amino-substituted- heterocyclic group which may have halogen, or a group of the formula: Image wherein R3 is lower alkyl, R2 is carboxy or a protected carboxy group, and A is lower alkylene which may have a substituent selected from the groups consisting of amino, a protected amino group, hydroxy, oxo and a group of the formula: =N~OR4, wherein R4 is hydrogen, cyclo(lower)- alkenyl, lower alkynyl, lower alkenyl, lower alkenyl substituted by carboxy or a protected carboxy group, lower alkyl, or lower alkyl substi- tuted by one or more substitutent(s) selected from carboxy, a protected carboxy group, amino, a protected amino group, cyano, phosphono, a protec- ted phosphono group and a heterocyclic group which may have suitable substituents and pharmaceuti- cally acceptable salts thereof; the derivatives of the invention are active against pathogenic microorganisms and can be used in treating infectious diseases.
364436
Kawabata Kohji
Masugi Takashi
Takasugi Hisashi
Takaya Takao
Yamanaka Hideaki
Fujisawa Pharmaceutical Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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