7.alpha.-(5-methylaminopentyl)-estratrienes, process for...

C - Chemistry – Metallurgy – 07 – J

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C07J 41/00 (2006.01) A61K 31/565 (2006.01) C07J 1/00 (2006.01) C07J 17/00 (2006.01) C07J 31/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2256344

The present invention relates to the novel 7.alpha.-(5-methylaminopentyl)- estratrienes of the general formula (I), in which R2 is a hydrogen or fluorine atom, R17 is a hydrogen atom, a methyl or ethynyl group, n is 2, 3 or 4, and x is 0, 1 or 2. The novel compounds are strong, pure anti-estrogenes and can be used to produce drugs to treat oestrogene-dependent diseases, for example, breast cancer, endometrial cancer, prostate hyperplasia, anovular infertility and melanoma.

L'invention concerne de nouveaux 7.alpha.-(5-méthylaminopentyl)-estratriènes de formule générale (I) dans laquelle R?2¿ représente un atome d'hydrogène ou de fluor; R?17¿ représente un atome d'hydrogène, un groupe méthyle ou éthinyle; n vaut 2, 3, ou 4 et x vaut 0, 1 ou 2. Ces nouveaux composés constituent de puissants anti-oestrogènes purs et peuvent être utilisés pour produire des médicaments servant à traiter des affections dépendant de l'oestrogène, par exemple le carcinome mammaire, le carcinome de l'endomètre, l'hyperplasie prostatique, l'infertilité anovulatoire et le mélanome.

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