7.alpha.-acylthio-15,16-methylene-3-oxo-17.alpha.-pregna-1,4...

Details 7.alpha.-acylthio-15,16-methylene-3-oxo-17.alpha.-pregna-1,4... 7.alpha.-acylthio-15,16-methylene-3-oxo-17.alpha.-pregna-1,4...

C - Chemistry, Metallurgy

07

J

260/21

C07J 31/00 (2006.01) C07J 53/00 (2006.01)

Patent

CA 1202301

Abstract of the Disclosure 7.alpha.-acylthio-15,16-methylene-3-oxo-17.alpha.- pregna-1,4-diene-21,17-carbolactones of the formula Image wherein the 15,16-methylene group can be in the .alpha.- or .beta.-configuration, and R is a lower alkyl residue, have altialdosterone activity. They are prepared from corresponding .DELTA.4- unsaturated compounds by chemical or microbiological 1,2-dehydrogenation.

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