7-(.alpha.,.alpha.-disubstituted-acetamido)-3-substituted-3-...

Details 7-(.alpha.,.alpha.-disubstituted-acetamido)-3-substituted-3-... 7-(.alpha.,.alpha.-disubstituted-acetamido)-3-substituted-3-...

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/24 (2006.01) C07C 45/00 (2006.01) C07C 45/71 (2006.01) C07C 51/16 (2006.01) C07C 59/84 (2006.01) C07C 59/88 (2006.01) C07C 59/90 (2006.01) C07C 205/56 (2006.01) C07D 333/24 (2006.01)

Patent

CA 1086717

ABSTRACT OF THE DISCLOSURE 7-(Disubstituted-acetamido)-3-substituted-3-cephem- 4-carboxylic acid and their process of preparation are provided of the formula Image wherein R1 is hydrogen, halogen, hydroxy, nitro, lower alkoxy or acylamino, R2 is hydrogen or acyl and R3 is lower alkanoyloxy, carbamoyloxy which may have lower alkyl, aryl or protective group for amino, or a heterocyclicthio which may have lower alkyl, and its derivatives at the carboxy group and pharmaceutically acceptable salts thereof; the novel compounds possess antibac- terial activity and inhibit the growth of a number of microorgan- isms including Gram-positive and Gram-negative bacteria.

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