C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/34 (2006.01) C07C 229/34 (2006.01) C07C 237/20 (2006.01) C07C 255/42 (2006.01) C07C 271/22 (2006.01) C07D 209/48 (2006.01)
Patent
CA 2243544
Novel compounds are of the formula Y1Y2N-(CH2)4-CH=C(Ph)-X wherein Y1 and Y2 are independently H or a removable blocking group, or Y1 and Y2 together are a removable divalent blocking group; and X is COOCH3 or a group convertible thereto. Such a compound may be cyclised, by Michael addition, to give methylphenidate, if necessary after removing blocking group(s) and converting X to COOCH3.
Nouveaux composants de formule Y?1¿Y?2¿N-(CH¿2?)¿4?-CH=C(Ph)-X dans laquelle Y?1¿ et Y?2¿ sont indépendamment H ou un groupe de blocage séparable, ou Y?1¿ et Y?2¿ représentent conjointement un groupe de blocage divalent séparable, X est COOCH¿3? ou un groupe pouvant être converti en COOCH¿3?. Un tel composant peut être cyclisé par addition Michael, pour former du méthylphénidate, si nécessaire après élimination du ou des groupe(s) de blocage et conversion de X en COOCH¿3?.
Fox Martin Edward
Paul Jane Marie
Borden Ladner Gervais Llp
Medeva Europe Limited
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