7-amino- isoindolyl compounds and their pharmaceutical uses

Details 7-amino- isoindolyl compounds and their pharmaceutical uses 7-amino- isoindolyl compounds and their pharmaceutical uses

C - Chemistry, Metallurgy

07

D

C07D 209/46 (2006.01) A61K 31/4035 (2006.01) A61K 31/428 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 275/06 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2518584

The invention encompasses 7-amido-isoindolyl compounds of formula (I) and methods of using these compounds and compositions in mammals for treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, cancer, inflammatory bowel disease and myelodysplastic syndrome.

La présente invention a trait à des composés de 7-amino-isoindolyle et des procédés d'utilisations de ces composés et compositions chez de mammifères pour le traitement, la prévention ou le contrôle de divers maladies et troubles, comprenant par exemple, mais de manière non exclusive, le cancer, la maladie intestinale inflammatoire et le syndrome myélodysplasique.

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