7 and 7-8 substituted 4,5.alpha. epoxymorphinan- 6-one...

Details 7 and 7-8 substituted 4,5.alpha. epoxymorphinan- 6-one... 7 and 7-8 substituted 4,5.alpha. epoxymorphinan- 6-one...

C - Chemistry, Metallurgy

07

D

260/237.65

C07D 489/02 (2006.01) C07D 221/28 (2006.01)

Patent

CA 1135691

Docket No. MS-1,102 7 AND 7-8 SUBSTITUTED 4,5.alpha. EPOXYMORPHINAN-6-ONE COMPOUNDS ABSTRACT OF THE DISCLOSURE Disclosed are 7 and 7-8 substituted 4,5.alpha. -epoxymorphinan-6-one compounds characterized by the structural formula: Image I In foregoing formula R' is cyclopropylmethyl or cyclobutylmethyl and R" is H or .beta.-methyl. The compounds cor- responding to the foregoing description are useful as mixed analgesics/narcotic antagonists.

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