7-and 8-aza-indolo-isoquinoline derivatives

Details 7-and 8-aza-indolo-isoquinoline derivatives 7-and 8-aza-indolo-isoquinoline derivatives

C - Chemistry, Metallurgy

07

D

260/273.5

C07D 471/04 (2006.01) C07D 209/90 (2006.01) C07D 209/94 (2006.01) C07D 471/06 (2006.01)

Patent

CA 1118423

ABSTRACT Isoquinoline compounds of the following formula are described: Image wherein the moiety A-B represents a group of formula : -CH2-NR3- or -NR3-CH2-; wherein R3 represents hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-4 alkyl, optionally substituted benzyl, C3-6 alkenyl or C1-4 alkanoyl; wherein R represents hydrogen, C1-6 alkyl, C3-6 cycloalkyl; or optionally substituted benzyl; wherein R1 and R2 each represent hydrogen or taken together represent a chemical bond; and wherein X is hydrogen or halogen; or an acid- addition salt thereof. The compounds have central nervous system activity.

327987

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