7-azabenzimidazoles with basic side chains

Details 7-azabenzimidazoles with basic side chains 7-azabenzimidazoles with basic side chains

C - Chemistry, Metallurgy

07

D

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C07D 471/04 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01)

Patent

CA 1103673

ABSTRACT OF THE DISCLOSURE 7-azabenzimidazoles of the formula Image where R1 and R2 are the same or different and are hydrogen, C1-C6- alkyl or C2-C6-alkanoyl, R3 is hydroxy, a mono C1-C6-alkylamino group or a di-C1-C6-alkylamino group, R4 is halogen, amino, mono C1-C6-alkylamino, di-C1-C6-alkylamino, mercapto, C1-C6-alkyl mer- capto, hydroxy or C1-C6-alkoxy, R5 is hydrogen or halogen and A is a C2-C6-alkylene group or pharmaceutically acceptable salt of such compounds are useful in treating ulcers and gastritis. Pre- ferably R1 and R2 are two equal C1-C6-alkyl groups, R? is hydroxy, mercapto, C1-C4-alkoxy, C1-C4-alkylmercapto or C1-C6 alkylamino, mercapto, C1-C6-alkylmercapto, hydroxy or C1-C6-alkoxy and R5 is hydrogen and pharmaceutically acceptable salts thereof.

312055

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