7-azaindole derivatives as selective 11-beta-hydroxysteroid...

Details 7-azaindole derivatives as selective 11-beta-hydroxysteroid... 7-azaindole derivatives as selective 11-beta-hydroxysteroid...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/33 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2704803

The present invention relates to 7-azaindole derivatives of formula (I) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1(11.beta.-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteo-porosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.

L'invention concerne des dérivés 7-azaindole de formule (1) servant d'inhibiteurs sélectifs de la 11-béta-hydroxystéroïde déshydrogénase de type 1 (11 ß-HSD-1 ). L'invention concerne également des procédés d'utilisation de tels composés permettant de traiter et de prévenir : un syndrome métabolique, le diabète, une résistance à l'insuline, l'obésité, des troubles lipidiques, un glaucome, l'ostéoporose, des troubles cognitifs, l'anxiété, la dépression, des troubles immunitaires, l'hypertension, ainsi que d'autres troubles et états pathologiques associés.

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