7-azaindoles and the use thereof as therapeutic agents

Details 7-azaindoles and the use thereof as therapeutic agents 7-azaindoles and the use thereof as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2523063

The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.

L'invention concerne des 7-azaindoles substitués de formule (I), des procédés de production de ces composés, des préparations pharmaceutiques contenant ces composés ainsi que l'utilisation pharmaceutique de ces composés, inhibiteurs de la phosphodiestérase 4, comme principes actifs dans le traitement de maladies nécessitant une inhibition de l'activité de la phosphodiestérase 4 en particulier dans des cellules immunocompétentes (p. ex. macrophages et lymphocytes) par les composés de la présente invention.

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