7-azaindoles and their use as ppar agonists

Details 7-azaindoles and their use as ppar agonists 7-azaindoles and their use as ppar agonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2580135

The invention relates to 7-azaindoles and to their physiologically acceptable salts and physiologically functional derivatives showing PPAR agonist activity. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance in involved.

La présente invention concerne des 7-azaindoles, leurs sels acceptables d'un point de vue physiologique, et leurs dérivés acceptables d'un point de vue fonctionnel, ayant une activité d'agoniste de PPAR. L'invention se rapporte à des composés de formule I dans laquelle les radicaux sont tels que définis, et à leurs sels acceptables d'un point de vue physiologique, ainsi qu'à des procédés pour les préparer. Ces composés conviennent à l'utilisation pour traiter et/ou prévenir des troubles du métabolisme des acides gras et des troubles de l'utilisation du glucose, ainsi que des troubles dans lesquels est impliquée la résistance à l'insuline.

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