C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/438 (2006.01) A61K 31/444 (2006.01) A61K 31/501 (2006.01) A61K 31/513 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2738776
Provided herein are 7-azaspiro[3.5]nonane-7-carboxamide compounds and the pharmaceutically acceptable salts of such compounds useful in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, conditions including including acute pain, chronic pain, neuropathic pain, nociceptive pain, inflammatory pain, cancer and cancer pain, fibromyalgia, rheumatoid arthritis, inflammatory bowel disease, lupus, diabetes, allergic asthma, vascular inflammation, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.
La présente invention concerne des composés 7-azaspiro[3.5]nonane-7-carboxamide et des sels pharmaceutiquement acceptables de tels composés utiles dans le traitement de maladies ou détats pathologiques associés à lactivité de lhydrolase damides dacides gras (FAAH), d'états pathologiques comprenant la douleur aiguë, la douleur chronique, la douleur neuropathique, la douleur nociceptive, la douleur inflammatoire, le cancer et la douleur liée au cancer, la fibromyalgie, larthrite rhumatoïde, la rectocolite hémorragique, le lupus, le diabète, l'asthme allergique, une vascularite, une incontinence urinaire, une vessie hyperactive, des vomissements, des troubles cognitifs, l'anxiété, la dépression, les troubles du sommeil, les troubles du comportement alimentaire, les troubles du mouvement, le glaucome, le psoriasis, la sclérose en plaques, des troubles cérébrovasculaires, une lésion cérébrale, des troubles gastro-intestinaux, l'hypertension, ou une maladie cardiovasculaire.
Long Scott Allen
Meyers Marvin Jay
Pelc Matthew James
Schweitzer Barbara Ann
Thorarensen Atli
Pfizer Inc.
Torys Llp
LandOfFree
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