7.beta.-[(2-amino-1,2-dioxoethyl)amino]acyl cephalosporin...

Details 7.beta.-[(2-amino-1,2-dioxoethyl)amino]acyl cephalosporin... 7.beta.-[(2-amino-1,2-dioxoethyl)amino]acyl cephalosporin...

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/20 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01)

Patent

CA 1121809

GG252/256 ABSTRACT 7.beta.-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]aacyl cephalosporins which have the formula Image wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, tri(lower alkyl)- stannyl, trihaloethyl or a salt forming ion; R1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R2 is hydrogen or methoxy; R3 is hydrogen, lower alkyl, phenyl-lower alkyl or cycloalkyl; R8 is hydrogen or -CR4R5-CN; R4 and R5 each is hydrogen or lower alkyl; and X is hydrogen, lower alkanoyloxy, carbamoyloxy, lower alkoxy, lower alkylthio Image , Image , or certain heterothio groups, are useful as antibacterial agents.

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