7-deazapurine derivatives and their production

Details 7-deazapurine derivatives and their production 7-deazapurine derivatives and their production

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 487/04 (2006.01) C07F 7/10 (2006.01) C07F 9/65 (1985.01)

Patent

CA 1247094

7-DEAZAPURINE DERIVATIVES AND THEIR PRODUCTION Abstract of the Disclosure 7-Deazapurine derivatives of the formula: Image wherein R1 is phenyl which has, at the ortho position and/or para position as substituents, at least one group represented by the formula -O-R3, -S-R4 or Image (wherein R3, R4, R5 and R6 are the same or different and each is hydrogen or an alkyl or phenyl group which maybe substituted, whereby R5 and R6, together with the adjacent nitrogen atom, may form a cyclic amino group which may be substituted, and R3, R4, R5 and R6 each may represent a protective group), and may have a group or groups with a molecular weight of up to about 200 as a substituent at any position other than those having the said substituents introduced; R2 is an amino group which may be protected, or its salt, have a potent antitumor activity, and hence the compounds are useful as an antitumor agent.

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