7-dithioalkylamino-mitosane analogs

Details 7-dithioalkylamino-mitosane analogs 7-dithioalkylamino-mitosane analogs

C - Chemistry, Metallurgy

07

D

260/299, 260/277

C07D 487/14 (2006.01)

Patent

CA 1288106

ABSTRACT This invention refers to 7-amino mitosane analogs (mitomycin C) in which the 7-amino group bears an organic substituent incorporating a disulfide group and to a novel thiol exchange process for producing these compounds. The compounds are inhibitors of experimental animal tumors. Some of the novel compounds produced by this process are represented by the structural formula: Image Formula IX

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