7-ether-taxol analogs, antineoplastic use and pharmaceutical...

Details 7-ether-taxol analogs, antineoplastic use and pharmaceutical... 7-ether-taxol analogs, antineoplastic use and pharmaceutical...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2191224

This invention provides 7-ether-taxol analogs of formula (I). The compounds of formula (I) are useful for the treatment of the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

L'invention concerne des analogues de 7-éther-taxol représentés par la formule (I). Ces composés peuvent s'utiliser dans le traitement de cancers, tels que ceux pour lesquels le taxol s'est avéré efficace, y compris le cancer des ovaires, le cancer du sein et le mélanoblastome, ainsi que pour le cancer des poumons, le cancer gastrique, le cancer du côlon, les cancers faciaux et cervicaux et la leucémie.

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