7-fluoro-dibenzo (b,f) thiepin derivatives

Details 7-fluoro-dibenzo (b,f) thiepin derivatives 7-fluoro-dibenzo (b,f) thiepin derivatives

C - Chemistry, Metallurgy

07

D

260/327.9

C07D 337/02 (2006.01) C07D 337/14 (2006.01)

Patent

CA 1175846

16573 ABSTRACT OF THE DISCLOSURE Novel 7-fluoro-dibenzo[b,f]thiepin derivatives of the formula: Image I wherein: n is an integer from 0 to 4; Z is thio, sulfinyl, or sulfonyl; A is 5-tetrazolyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, or 4-hydroxy-2,5-dioxo-.DELTA.3-pyrrolin-3-yl, or Image wherein R2 is hydroxy, lower alkyl, lower alkoxy, N,N-diloweralkylaminoloweralkoxy, hydroxylower- alkoxy, carboxyloweralkoxy, amino, N-loweralkyl- amino, N,N-diloweralkylamino, loweralkylsulfonyl- amino, carboxyloweralkylamino, carboxamidolower- alkylamino, and 2-imino-3-methylthiazolidine; and the dotted line indicates either an olefinic bond or saturation at the 10-,11-position; and the pharmaceutically acceptable salts thereof.

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