7-halo- and 7beta,8beta-methano-taxols, antineoplastic use...

Details 7-halo- and 7beta,8beta-methano-taxols, antineoplastic use... 7-halo- and 7beta,8beta-methano-taxols, antineoplastic use...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/695 (2006.01) C07D 263/04 (2006.01) C07D 263/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/02 (2006.01) C07D 413/12 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2149021

2149021 9413655 PCTABS00032 This invention provides 7-deoxy-taxol analogs of formula (I). The compounds of formula (I) (including formulae II and III) are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

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