C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/22 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61P 15/00 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01) C07D 333/00 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07D 495/14 (2006.01)
Patent
CA 2431617
The present invention is directed to novel 7-heterocyclyl quinoline and thieno[2,3-b]pyridine derivatives of the general formula (I) or (II), wherein all variables are as herein defined, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions associated with gonadotropin releasing hormone (GnRH). The compounds of the invention are antagonists of GnRH, useful in the treatment of the infertility, prostate cancer, benign prostate hyperplasia (BPH) and as contraceptives.
La présente invention concerne des nouveaux dérivés de 7-hétérocyclyle quinoline et de thiéno[2,3-b]pyridine de formule générale (I) ou (II), dans laquelle toutes les variables sont telles que définies dans la description. L'invention concerne également des compositions pharmaceutiques renfermant lesdits composés, ainsi que leurs utilisations dans le traitement de troubles et d'états pathologiques associés à la gonadolibérine (GnRH). Les composés de l'invention sont des antagonistes de GnRH utiles dans le traitement de l'infertilité, du cancer de la prostate et de l'hyperplasie prostatique bénigne (HBP). On peut en outre les utiliser comme contraceptifs.
Lanter James C.
Macielag Mark
Sui Zhihua
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Mcneil Pharmaceutical Inc.
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