7-hexanoyltaxol and methods for preparing the same

Details 7-hexanoyltaxol and methods for preparing the same 7-hexanoyltaxol and methods for preparing the same

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/335 (2006.01)

Patent

CA 2327791

An antitumor compound of formula (5). Also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the 2' and 7 positions of paclitaxel is followed by the hydrolysis of the 2' hexanoate group resulting in 7-hexanoyltaxol.

L'invention concerne un composé antitumoral de formule (5), ainsi qu'un procédé permettant de préparer ledit composé. Le procédé consiste à diestérifier les groupes alcool situés aux positions 2' et 7 du paclitaxel, puis à hydrolyser le groupe 2'-hexanoate, de façon à obtenir le 7-hexanoyltaxol.

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