7 human ovarian and ovarian cancer associated proteins

Details 7 human ovarian and ovarian cancer associated proteins 7 human ovarian and ovarian cancer associated proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2400638

This invention relates to newly identified ovarian or ovarian cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "ovarian cancer antigens", and the use of such ovarian antigens for detecting disorders of the reproductive system, particularly the presence of ovarian cancer and ovarian cancer metastases. This invention relates to ovarian cancer antigens as well as vectors, host cells, antibodies directed to ovarian cancer antigens and the recombinant methods and synthetic methods for producing the same. Also provided are diagnostic methods for detecting, treating, preventing and/or prognosing disorders related to the ovary, including ovarian cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of ovarian cancer antigens of the invention. The present invention further relates to inhibiting the production and function of the polypeptides of the present invention.

L'invention concerne de nouveaux polynucléotides ovariens ou associés au cancer des ovaires et les polypeptides codés par ces polynucléotides désignés collectivement <= antigènes du cancer des ovaires >=, et l'utilisation de ces antigènes ovariens afin de détecter des troubles du système reproductif, en particulier, la présence d'un cancer des ovaires ou de métastases du cancer des ovaires. Elle concerne des antigènes du cancer des ovaires, ainsi que des vecteurs, des cellules hôtes, des anticorps dirigés contre des antigènes du cancer des ovaires, les procédés de recombinaison et les procédés de synthèse servant à les préparer. Elle concerne également des procédés diagnostiques servant à détecter, traiter, prévenir et/ou pronostiquer des troubles associés aux ovaires, y compris le cancer des ovaires, et des procédés thérapeutiques servant à traiter ces troubles. Elle concerne, de plus, des procédés de criblage servant à identifier des agonistes et des antagonistes de ces antigènes du cancer des ovaires. Elle concerne également l'inhibition de la production et du fonctionnement de ces polypeptides.

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