7-hydroxy-oestradiols

Details 7-hydroxy-oestradiols 7-hydroxy-oestradiols

C - Chemistry, Metallurgy

07

J

260/21, 195/25,

C07J 7/00 (2006.01) C07J 1/00 (2006.01) C07J 17/00 (2006.01) C07J 31/00 (2006.01)

Patent

CA 1054143

ABSTRACT OF THE DISCLOSURE A 7-hydroxy-oestradiol of the general formula I (I), Image which possesses a strong vaginotropic and weak uterotropic action, is produced, for example, by treating a compound of the general formula II (II), Image with an agent capable of introducing into the 17.alpha.-position an unsubstituted, saturated lower hydrocarbon group, an unsubstit- uted, unsaturated lower hydrocarbon group or a chlorine-substit- uted, unsaturated lower hydrocarbon group. In the above formula, in which the group OR2 is in the .alpha.- or .beta.-position; R1 represents a hydrogen atom, an acyl group, an unsubstituted or substituted alkyl group, a cycloalkyl group, a saturated heterocyclic group containing an oxygen hetero atom, or a sulphonic acid group; R2 and R3 each represents a hydrogen atom, an acyl group or a sat- urated heterocyclic group containing an oxygen hetero atom, and R2 may also represent a sulphonic acid group; and R4 represents an unsubstituted, saturated lower hydrocarbon group, an unsub- stituted, unsaturated lower hydrocarbon group or a chlorine- substituted, unsaturated lower hydrocarbon group.

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