7-imino derivatives of camptothecin having antitumor activity

Details 7-imino derivatives of camptothecin having antitumor activity 7-imino derivatives of camptothecin having antitumor activity

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 211/00 (2006.01) C07D 221/00 (2006.01) C07D 311/00 (2006.01)

Patent

CA 2517450

Camptothecin derivatives of camptothecin of formula (I), wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.

L'invention concerne des dérivés de camptothécine représentés par la formule (I), dans laquelle les groupes R¿1?, R¿2? et R¿3? sont tels que définis dans le descriptif. Les composés représentés par la formule (I) présentent une activité antitumorale et un bon indice thérapeutique. L'invention concerne aussi des procédés de préparation des composés représentés par la formule (I) ainsi que leur utilisation dans la préparation de médicaments destinés à traiter des tumeurs et des infections virales, et de médicaments possédant une activité antiplasmodium falciparum.

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