7-methoxycephalosporin

Details 7-methoxycephalosporin 7-methoxycephalosporin

C - Chemistry, Metallurgy

07

D

260/102

C07D 501/24 (2006.01) A61K 31/545 (2006.01) C07D 501/04 (2006.01) C07D 501/20 (2006.01) C07D 501/28 (2006.01) C07D 501/32 (2006.01) C07D 501/34 (2006.01) C07D 501/36 (2006.01) C07D 501/40 (2006.01) C07D 501/44 (2006.01) C07D 501/46 (2006.01) C07D 501/56 (2006.01) C07D 501/60 (2006.01) C07D 501/57 (2006.01)

Patent

CA 1086716

ABSTRACT OF THE DISCLOSURE A cephalosporin of the formula (I): Image (I) wherein A is a mono- or polycyclic heteroaromatic ring containing at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted; R is a phenyl group which may be unsubstituted or substituted, a thienyl group, a furyl group, a cyclohexadienyl group or a cyclohexenyl group; X is an acetoxy group, a pyridinium group which may be unsubstituted or substituted with a methyl or carbamoyl group, a group of the formula: Image in which R1 and R2, which may be the same or different, each is a hydrogen atom or a (C1 - C4) alkyl group, or a group of the formula: -S-Het in which Het is a heterocyclic ring containing 1 to 5 oxygen, nitrogen and sulfur atoms as a hetero atom, in which the hetero- cyclic ring system may be either polycyclic or 5- or 6-membered monocyclic and may be unsubstituted or substituted; and M is a hydrogen atom or a biologically active carboxyl-protecting group, or is an anionic charge only when X is a pyridinium group; and the pharmaceutically acceptable salts thereof, which are useful as antimicrobil agents and prepared by the reaction of a compound of the formula (II): Abstract continued: HO-A-COOH (II) wherein A is as defined above, or a reactive derivative thereof, with a compound of the formula (III): Image (III) wherein R, M and X are as defined above, or a derivative thereof.

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