7-methoxycephalosporin derivatives

Details 7-methoxycephalosporin derivatives 7-methoxycephalosporin derivatives

C - Chemistry, Metallurgy

07

D

260/101, 260/102

C07D 501/20 (2006.01) A61K 31/545 (2006.01) C07D 501/04 (2006.01) C07D 501/22 (2006.01) C07D 501/24 (2006.01)

Patent

CA 1064478

7-METHOXYCEPHALOSPORIN DERIVATIVES Abstract of the disclosure A compound of the formula: Image wherein R2 is hydrogen or a halogen and R3 stands for methyl, acetoxymethyl, carbamoyloxymethyl, an alkoxymethyl, an alkylthiomethyl, 2-carboxy-1-ethenyl, or a heterocyclic thiomethyl, or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against Gram-negative bacteria including Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Serratia marcescense as well as Gram-positive ones including antibiotic resistant strains. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.

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