C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/237.69
C07D 221/28 (2006.01)
Patent
CA 1135692
Docket No. MS-1,088 7-METHYL AND 7-METHYL-8-LOWER ALKYL B/C CIS OR TRANS MORPHINAN-6-ONE COMPOUNDS ABSTRACT OF THE DISCLOSURE Disclosed are 7-methyl and 7-methyl-8-lower alkyl substituted B/C Cis or Trans morphinan-6-one compounds characterized by the structural formula: Image I Specific compounds, included within the scope of the foregoing general formula wherein R1 is H or methyl, R2 is cyclopropylmethyl or cyclobutylmethyl and R3 is H, methyl or ethyl are useful as mixed analgesics /narcotic antagonists.
350957
Kotick Michael P.
Leland David L.
Polazzi Joseph O.
Schut Robert N.
Miles Laboratories Inc.
Osler Hoskin & Harcourt Llp
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