7-methyl and 7-methyl-8-lower alkyl b/c cis or trans...

C - Chemistry – Metallurgy – 07 – D

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260/237.69

C07D 221/28 (2006.01)

Patent

CA 1135692

Docket No. MS-1,088 7-METHYL AND 7-METHYL-8-LOWER ALKYL B/C CIS OR TRANS MORPHINAN-6-ONE COMPOUNDS ABSTRACT OF THE DISCLOSURE Disclosed are 7-methyl and 7-methyl-8-lower alkyl substituted B/C Cis or Trans morphinan-6-one compounds characterized by the structural formula: Image I Specific compounds, included within the scope of the foregoing general formula wherein R1 is H or methyl, R2 is cyclopropylmethyl or cyclobutylmethyl and R3 is H, methyl or ethyl are useful as mixed analgesics /narcotic antagonists.

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