7-(n-substituted amino)-2-phenylheptanoic acid derivative...

C - Chemistry – Metallurgy – 07 – C

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C07C 229/34 (2006.01) C07C 271/22 (2006.01) C07C 309/73 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2211930

Disclosed is a 7-(N-substituted amino)-3-oxo-2- phenylheptanoate derivative, 7-(N-substituted amino)-3- hydroxy-2-phenylheptanoate derivative, and 7-(N- substituted amino)-3-benzenesulfonyloxy-2- phenylheptanoate derivative, which are quite important major intermediates for an antidepressant. The 7-(N- substituted amino)-3-oxo-2-phenylheptanoate derivative can be manufactured by condensing an enolate of phenylacetates with a 5-(N-substituted amino)pentanoate derivative.

L'invention porte sur un dérivé du 7-(amino N-substituté)-3-oxo-2-phénylheptanoate, sur un dérivé du 7-(amino N-substituté)-3-hydroxy-2-phénylheptanoate et sur un dérivé du 7-(amino N- substituté)-3-benzènesulfonyloxy-2-phénylheptanoate, qui constituent des intermédiaires très importants d'un antidépresseur. Le dérivé du 7-(amino N-substituté)-3-oxo-2-phénylheptanoate peut être fabriqué par condensation d'un énolate de phénylacétates avec un dérivé du 5-(amino N-substituté)pentanoate.

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