7-oxabicyclo(2.2.1)heptane analogs

Details 7-oxabicyclo(2.2.1)heptane analogs 7-oxabicyclo(2.2.1)heptane analogs

C - Chemistry, Metallurgy

07

D

167/245, 260/367

C07D 493/08 (2006.01) A61K 31/335 (2006.01)

Patent

CA 1284648

7-OXABICYCLO(2.2.1)HEPTANE ANALOGS 7-Oxabicyclo(2.2.1)heptane analogs are disclosed having the general formula Image wherein R1 is lower alkyl, alkenyl, substituted alkenyl or alkynyl; R2 is lower alkyl, alkenyl or alkynyl; A is -CH2-CH?CH- or a single bond; X is -CH2, -CH(CH3) or -C(CH3)2; n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9; including all stereoisomers. These new compounds have been found to be inhibitors of arachidonic acid cyclooxygenase and are therefore useful as antiinflammatory antipyretic and analgesic agents.

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