7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of...

Details 7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of... 7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of...

C - Chemistry, Metallurgy

07

D

167/245, 260/361

C07D 493/08 (2006.01) A61K 31/34 (2006.01)

Patent

CA 1296344

QA197 Abstract 7-OXABICYCLO(2.2.1)HEPTANE ANALOGS USEFUL AS INHIBITORS OF 5-LIPOXYGENASE AND CYCLOOXYGENASE A compound of the formula Image wherein R1 is hydrogen, hydroxy, alkoxy or aryloxy; R2 is hydrogen, hydroxy, alkoxy or aryloxy; or wherein R1 and R2 taken together is an aromatic ring; R3 is hydrogen or lower alkyl; R4 is lower alkyl, substituted alkyl, alkenyl or alkynyl; X is CH2, amino, alkylamino, alkanoylamino, oxygen or a single bond; A is CH2?CH?CH or a single bond; and n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9; including all stereoisomers thereof. These new compounds have been found to simultaneously inhibit the arachidonic acid enzymes 5-lipoxygenase and cyclooxygenase and as such are useful, for example, as antiinflammatory agents.

542323

Affiliated with

Also associated with

Rating

7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1233479