7-oxabicyclo(2.2.1)heptane hydroxamic acid derivatives...

Details 7-oxabicyclo(2.2.1)heptane hydroxamic acid derivatives... 7-oxabicyclo(2.2.1)heptane hydroxamic acid derivatives...

C - Chemistry, Metallurgy

07

D

167/245, 260/361

C07D 493/08 (2006.01) A61K 31/34 (2006.01) A61K 31/557 (2006.01)

Patent

CA 1301179

QA194 ABSTRACT 7-OXABICYCLO(2.2.1)HEPTANE HYDROXAMIC ACID DERIVATIVES USEFUL AS "DUAL INHIBITORS" 7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives are disclosed having the general formula Image wherein R1 is hydrogen, lower alkyl, aryl, aralkyl or alkenyl; R2 is hydrogen, lower alkyl, alkanoyl or aroyl; R3 is lower alkyl, alkenyl or alkynyl; A is -CH2 -CH=CH- or a single bond; and n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9; and including all stereoisomers and pharmaceutically acceptable salts thereof. These new compounds have been found to simultaneously inhibit the arachidonic acid enzymes cyclooxygenase and 5-lipoxygenase and are therefore useful as antiinflammatory, antiasthma and antipsoriatic agents.

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