7-oxabicycloheptane imidazole prostaglandin analogs useful...

Details 7-oxabicycloheptane imidazole prostaglandin analogs useful... 7-oxabicycloheptane imidazole prostaglandin analogs useful...

C - Chemistry, Metallurgy

07

D

167/237, 260/305

C07D 493/08 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2036486

HA495a Abstract 7-OXABICYCLOHEPTANE IMIDAZOLE PROSTAGLANDIN ANALOGS USEFUL IN THE TREATMENT OF THROMBOTIC AND VASOSPASTIC DISEASE 7-Oxabicycloheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula Image , wherein m is 0, 1, 2, 3 or 4; n is 1, 2 or 3: and p is 1, 2 or 3; Z is -CH=CH-, -CH2CH2- or Image wherein Y is 0 or a single bond; R is CO2H, CO2lower alkyl, CO2alkali metal, CONHSO2R2 (wherein R2 is lower alkyl or aryl) or -CH2-5-tetrazolyl; A is CHOH, C=O, Image (wherein R3 is H or lower alkyl), or a single bond; R1 is lower alkyl, aryl, cyclo- alkyl or H, R1 can be H only when A is a single bond.

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