7-oxabicycloheptane imino interphenylene substituted...

Details 7-oxabicycloheptane imino interphenylene substituted... 7-oxabicycloheptane imino interphenylene substituted...

C - Chemistry, Metallurgy

07

D

167/205, 260/361

C07D 491/08 (2006.01) A61K 31/557 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2001028

HA479 Abstract 7-OXABICYCLOHEPTANE IMINO INTERPHENYLENE SUBSTITUTED PROSTAGLANDIN ANALOGS USEFUL IN THE TREATMENT OF THROMBOTIC DISEASE 7-Oxabicycloheptane imino interphenylene substituted prostaglandin analogs are provided having the structural formula Image wherein n is 1 or 2; m is 1 or 2; R is H, lower alkyl, or alkali metal; and R1 is -OR2, Image or Image where R2 is lower alkyl, aryl, aralkyl, cycloalkylalkyl, alkanoyl or aroyl; and R3 is lower alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, -NHaralkyl, -NHalkyl, -NHalkylcycloalkyl or -NHaryl. These compounds are cardiovascular agents which exhibit thromboxane antagonist activity and thus are useful in the treatment of thrombotic and vasospastic disease.

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