7-oxabicycloheptane substituted amide-carbamate...

Details 7-oxabicycloheptane substituted amide-carbamate... 7-oxabicycloheptane substituted amide-carbamate...

C - Chemistry, Metallurgy

07

D

167/205, 260/361

C07D 493/08 (2006.01) A61K 31/335 (2006.01) A61K 31/41 (2006.01)

Patent

CA 1285570

Abstract 7-OXABICYCLOHEPTANE SUBSTITUTED AMIDE-CARBMATE PROSTAGLANDIN ANALOGS 7-Oxabicycloheptane substituted amide-carbamide prostaglandin analogs are provided having the structural formula Image wherein m is 0 to 4; A is -CH=CH- or -CH2-CH2-; n is 1 to 5; Q is -CH=CH-, -CH2-, Image , Image , Image , or a single bond; R is CO2H, CO2alkyl, CO2alkali metal, CO2polyhydroxyamine salt, -CH2OH, Image , or ?NR3R4 wherein R3 and R4 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R3 and R4 being other than hydroxy and lower alkoxy; p is 1 to 5; R1 is H or lower alkyl; q is 1 to 12; and R2 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, or arylalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

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