7-oxabicycloheptane substituted aminoalkyl amide...

Details 7-oxabicycloheptane substituted aminoalkyl amide... 7-oxabicycloheptane substituted aminoalkyl amide...

C - Chemistry, Metallurgy

07

D

167/233, 167/245

C07D 493/08 (2006.01) A61K 31/34 (2006.01) A61K 31/41 (2006.01)

Patent

CA 1285953

Abstract 7-OXABICYCLOHEPTANE SUBSTITUTED AMINOALKYL AMIDE PROSTAGLANDIN ANALOGS 7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula Image wherein m is 0 to 4; A is -CH=CH- or -CH2-CH2-; n is 1 to 5; R is CO2H, CO2alkyl, CO2alkali metal, CO2polyhydroxyamine salt, -CH2OH, Image or Image wherein R4 and R5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R4 and R5 being other than hydroxy and lower alkoxy; p is 1 to 4; R1 is H or lower alkyl; q is 1 to 12; R2 and R3 are the same or different and are H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy, cycloalkyl or cycloalkylalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

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