7-oxabicycloheptane substituted aryl amino prostaglandin...

Details 7-oxabicycloheptane substituted aryl amino prostaglandin... 7-oxabicycloheptane substituted aryl amino prostaglandin...

C - Chemistry, Metallurgy

07

D

167/245, 260/361

C07D 493/08 (2006.01) A61K 31/34 (2006.01) A61K 31/557 (2006.01)

Patent

CA 1249291

ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED ARYL AMINO PROSTAGLANDIN ANALOGS AND THEIR USE IN INHIBITING PLATELET AGGREGATION AND BRONCHOCONSTRICTION 7-Oxabicycloheptane substituted arylamino prostaglandin analogs are provided having the structural formula Image wherein A is -CH=CH- or -(CH2)2-; m is 1 to 8; n is 1 to 5; R is H, lower alkyl, alkali metal or a polyhydroxyamino salt; R1 is H, lower alkyl, hydroxyalkyl or aryl; R2 is H, lower alkyl, aryl or cycloalkyl, R3 is substituted aryl wherein the aryl group (which may be phenyl or naphthyl) is substituted with one or two of the following groups: hydroxy, Image , Image , Image , SR4, -CN, Image , wherein R4 and R5 may be the same or different and are H or lower alkyl, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

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