7-oxabicycloheptane substituted diacid diamide prostaglandin...

Details 7-oxabicycloheptane substituted diacid diamide prostaglandin... 7-oxabicycloheptane substituted diacid diamide prostaglandin...

C - Chemistry, Metallurgy

07

D

167/233, 167/245

C07D 493/08 (2006.01) A61K 31/34 (2006.01) A61K 31/41 (2006.01)

Patent

CA 1286679

ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED DIACID DIAMIDE PROSTAGLANDIN ANALOGS New 7-oxabicycloheptane substituted diacid diamide prostaglandin analogs are cardiovascular agents useful, for example, in the treatment of thorombotic disease and have the structural formula Image including all stereoisomers thereof, wherein m is 0 to 4; A is -CH=CH- or -CH2-CH2-; n is 1 to 5; Q is -CH=CH-, -CH2-, Image , Image , Image , or a single bond; R is-CO2H,-CO2alkyl, -CO2alkali metal,-CO2polyhydroxyamine salt, -CH2OH, Image , or -?NR4R5 wherein R4 and R5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R4 and R5 being other than hydroxy and lower alkoxy; p is 1 to 4; R1 is H or lower alkyl; q is 1 to 12; R2 and R3 are the same or different and are H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy or cycloalkyl.

515054

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