7-oxabicycloheptane substituted keto-amide prostaglandin...

Details 7-oxabicycloheptane substituted keto-amide prostaglandin... 7-oxabicycloheptane substituted keto-amide prostaglandin...

C - Chemistry, Metallurgy

07

D

167/233, 167/245

C07D 493/08 (2006.01) A61K 31/34 (2006.01) C07D 257/04 (2006.01)

Patent

CA 1284644

Abstract 7-OXABICYCLOHEPTANE SUBSTITUTED KETO-AMIDE PROSTAGLANDIN ANALOGS 7-Oxabicycloheptane substituted keto-amide prostaglandin analogs are provided having the structural formula Image wherein m is 0 to 4; A is -CH=CH- or -CH2-CH2-; n is 1 to 5; Q is -CH=CH-, -CH2-, Image , Image , or a single bond; R is CO2H, CO2alkyl, CO2alkali metal, CO2polyhydroxyamine salt, Image , or ?NR4R5 wherein R4 and R5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R4 and R5 being other than hydroxy and lower alkoxy; p is 1 to 4; R1 is H or lower alkyl; and R2 is H, lower alkyl, lower alkenyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

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