7-oxabicycloheptane substituted oxa prostaglandin analogs

Details 7-oxabicycloheptane substituted oxa prostaglandin analogs 7-oxabicycloheptane substituted oxa prostaglandin analogs

C - Chemistry, Metallurgy

07

D

167/205, 167/245

C07D 493/08 (2006.01) A61K 31/34 (2006.01) A61K 31/557 (2006.01)

Patent

CA 1256888

ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED OXO PROSTAGLANDIN ANALOGS 7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula Image wherein R is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R1 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl or cyclo- alkylalkyl, A is -CH=CH- or -(CH2)2-, y is 0 to 4, m is 0 to 8, and n is 1 to 4, p is 1 to 12 and q is 0 to 5, and including all stereoisomers thereof. The compounds are antiinflammatory agents useful, for axample, in the treatment of inflammatory diseases and analgesic agents as well as cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

477304

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