7-oxabicycloheptane substituted oxa prostaglandin analogs

Details 7-oxabicycloheptane substituted oxa prostaglandin analogs 7-oxabicycloheptane substituted oxa prostaglandin analogs

C - Chemistry, Metallurgy

07

D

167/205, 167/245

C07D 493/08 (2006.01) A61K 31/34 (2006.01) A61K 31/557 (2006.01)

Patent

CA 1257285

ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED OXO PROSTAGLANDIN ANALOGS 7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula Image wherein R,is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R1 and R2 may be the same or different and are hydrogen or lower alkyl, R3 is hydrogen, lower alkyl, aryl or cycloalkyl, A is -CH=CH- or -(CH2)2-, m is 1 to 8, and n is 1 to 4, p is 1 to 12 and q is 0 to 5, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

471793

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