7-oxabicycloheptane substituted oxa prostaglandin analogs

Details 7-oxabicycloheptane substituted oxa prostaglandin analogs 7-oxabicycloheptane substituted oxa prostaglandin analogs

C - Chemistry, Metallurgy

07

D

167/233, 167/245

C07D 493/08 (2006.01) A61K 31/34 (2006.01) A61K 31/41 (2006.01) C07D 493/18 (2006.01)

Patent

CA 1266668

HA342 ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED OXA PROSTAGLANDIN ANALOGS 7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula Image wherein R1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is -CH=CH- or -(CH2)2-, n is 1 to 4, m is 1 to 8, and 2 is Image wherein R3 is lower alkyl, aryl or arylalkyl; or Image wherein R4 is H or lower alkyl and including all stereoisomers thereof.

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