7-oxabicycloheptane substituted prostaglandin alcohols

Details 7-oxabicycloheptane substituted prostaglandin alcohols 7-oxabicycloheptane substituted prostaglandin alcohols

C - Chemistry, Metallurgy

07

D

167/245, 260/367

C07D 493/08 (2006.01) A61K 31/34 (2006.01)

Patent

CA 1262140

ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED PROSTAGLANDIN ALCOHOLS 7-Oxabicycloheptane substituted prosta- glandin alcohols are provided having the structural formula Image wherein A is -CH=CH-(CH2)n- or (CH2)q; B is a single bond or -CH=CH-; n is 1 to 5; q is 1 to 6; Q is -CH=CH- or (CH2)2; and R is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, with the proviso that when B is -CH=CH-, n is 1 to 3 or q is 1 to 4 and when B is a single bond, n is 1 to 5 or q is 1 to 6, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

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